Correction: Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases
نویسندگان
چکیده
Macrosomia is associated with considerable neonatal and maternal morbidity. Factors that predict macrosomia are poorly understood. The increased rate of macrosomia in the offspring of pregnant women with diabetes and in congenital hyperinsulinaemia is mediated by increased foetal insulin secretion. We assessed the in utero and neonatal role of two key regulators of pancreatic insulin secretion by studying birthweight and the incidence of neonatal hypoglycaemia in patients with heterozygous mutations in the maturity-onset diabetes of the young (MODY) genes HNF4A (encoding HNF-4a) and HNF1A/TCF1 (encoding HNF-1a), and the effect of pancreatic deletion of Hnf4a on foetal and neonatal insulin secretion in mice.
منابع مشابه
Structures of two coronavirus main proteases: implications for substrate binding and antiviral drug design.
Coronaviruses (CoVs) can infect humans and multiple species of animals, causing a wide spectrum of diseases. The coronavirus main protease (M(pro)), which plays a pivotal role in viral gene expression and replication through the proteolytic processing of replicase polyproteins, is an attractive target for anti-CoV drug design. In this study, the crystal structures of infectious bronchitis virus...
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ورودعنوان ژورنال:
- PLoS Biology
دوره 3 شماره
صفحات -
تاریخ انتشار 2005